New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling

• Elenilson F. da Silva,
• Krist Helen Antunes Fernandes,
• Denise Diedrich,
• Jessica Gotardi,
• Marcia Silvana Freire Franco,
• Carlos Henrique Tomich de Paula da Silva,
• Ana Paula Duarte de Souza and
• Simone Cristina Baggio Gnoatto

Beilstein J. Org. Chem. 2022, 18, 1524–1531, doi:10.3762/bjoc.18.161

• the same region occupied by crystallographic ligands in their complex with IMPDH. The results obtained in this study suggest that compound 8 might be a new anti-RSV candidate. Keywords: antiviral; betulinic acid; bioisosterism; respiratory syncytial virus; triterpene; ursolic acid; Introduction

• ]. Ursanes, represented by ursolic acid and lupanes, represented by betulinic acid, both natural pentacyclic triterpenes, are commonly found in several plant species could provide interesting prototypes for developing new antivirals, more specifically anti-RSV compounds [21]. Betulinic (1) and ursolic (2

• = 44.4 and 14.29 µM, respectively). Although betulinic acid (1) exhibited greater antiviral activity than ursolic acid (2), the introduction of a nitroaryl-1,2,3-triazole substituent in 2 was more efficient than its introduction in scaffold 1. Moreover, all tested compounds showed low cytotoxicity in

Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants

• Karan Malhotra and
• Jakob Franke

Beilstein J. Org. Chem. 2022, 18, 1289–1310, doi:10.3762/bjoc.18.135

• , which plays a central role in the diversification of triterpenoids in eudicots [79]. Members of the CYP716A subfamily were mostly identified as C28 oxidases that catalyse three-step oxidation of α-amyrin (7), β-amyrin (6) and lupeol (10) to ursolic acid, oleanolic acid, and betulinic acid, respectively

Terpenoids from Glechoma hederacea var. longituba and their biological activities

• Dong Hyun Kim,
• Song Lim Ham,
• Zahra Khan,
• Sun Yeou Kim,
• Sang Un Choi,
• Chung Sub Kim and
• Kang Ro Lee

Beilstein J. Org. Chem. 2022, 18, 555–566, doi:10.3762/bjoc.18.58

• -3α,12α,16α-triol (6) [15], 3-epimaslinic acid (7) [18], oleanolic acid (8) [19], and ursolic acid (9) [20]. To find potential antineuroinflammatory, neurotrophic, and cytotoxic secondary metabolites from G. hederacea var. longituba, the isolated compounds (1–9) were evaluated for these biological